Coronavirus Disease 2019 (COVID-19) Breakthrough Infection and Post-Vaccination Neutralizing Antibodies Among Healthcare Workers in a Referral Hospital in Tokyo: A Case-Control Matching Study코로나 바이러스 질병 2019(COVID-19) 도쿄의 위탁 병원에서 의료 종사자 사이의 획기적인 감염 및 백신 접종 후 중화 항체: 사례-대조군 일치 연구Article Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 변종, 진단, [키워드] Alpha Alpha variant anti-spike antibodies anti-spike antibody Antibody titers Asymptomatic B.1.1.7 B.1.617.2 BNT162b2 Breakthrough infection Cohort Control controls coronavirus disease Coronavirus disease 2019 Coverage COVID-19 COVID-19 case COVID-19 cases Delta delta variant effective vaccine Effective vaccines Epidemic epidemic wave groups hospital Japan live virus live viruses matched controls matching measure Mild Neutralizing Neutralizing antibodies neutralizing antibody Neutralizing antibody titer Neutralizing titer neutralizing titers not decreased occurred outbreak participant Patient Quantitative assays raise Referral returned selected strain Strains the epidemic Tokyo vaccination vaccination. variant variants viruses while wild-type worker [DOI] 10.1093/cid/ciab1048 PMC 바로가기 [Article Type] Article
SARS-CoV2 mRNA Vaccine-Specific B-, T- and Humoral Responses in Adolescents After Kidney Transplantation신장 이식 후 청소년의 SARS-CoV2 mRNA 백신 특이적 B, T 및 체액 반응Article Published on 2022-08-042022-09-12 Journal: Transplant International [Category] SARS, 진단, [키워드] Adolescent adolescents Adults age analyzed approval Arm B cell B-cell response BNT162b2 CD4 controls cytokine production feature Frequency healthy control Humoral response identify IGD IgG Immunity in both groups kidney kidney transplant recipient Kidney transplantation limitation magnitude majority memory memory cell mRNA neutralizing titers outcome Patient patients Pfizer/BioNTech protection reactogenicity recipients reduced response robust SARS-CoV2 Seroconversion shown significantly Still T cell transplantation Treatment vaccination vaccination. Vaccines [DOI] 10.3389/ti.2022.10677 PMC 바로가기 [Article Type] Article
Vaccine based on folded receptor binding domain-PreS fusion protein with potential to induce sterilizing immunity to SARS-CoV-2 variantsSARS-CoV-2 변이체에 대한 살균 면역을 유도할 수 있는 접힌 수용체 결합 도메인-PreS 융합 단백질 기반 백신Article Published on 2022-08-012022-09-11 Journal: Allergy [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus antibody Antibody Response Antigen C-terminus carrier cellular combination vaccine construction convalescent coronavirus COVID-19 COVID-19 pandemic fused fusion protein Genetic genotypes HBV healthy subject healthy subjects hepatitis B Hepatitis B virus human cell human cells IgG IgG antibodies IgG antibody IgG response Immunity immunized in vitro in vivo induce inhibited Interaction maintenance median mucosal secretions Neutralizing Neutralizing antibodies neutralizing antibody neutralizing titers Omicron variant pandemic Protein random Random sample RBD RBD-specific IgG RBD-specific IgG response receptor ACE2 Receptor binding Receptor-binding domain recombinant fusion protein Registered replicate respiratory response responsible robust SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 variant SARS-CoV-2 variants serum severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 specific antibodies specific IgG antibodies spike Spike protein sterilizing immunity subject subjects subunit Subunit vaccine surface antigen sustained Vaccine vaccine. Viral viral replication virus entry virus-neutralizing VNT [DOI] 10.1111/all.15305 PMC 바로가기 [Article Type] Article
Immunogenicity of SARS-CoV-2 Trimeric Spike Protein Associated to Poly(I:C) Plus Alum폴리(I:C) 플러스 명반과 관련된 SARS-CoV-2 삼량체 스파이크 단백질의 면역원성Article Published on 2022-06-302022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] addition adjuvant adjuvants alum antibody B cell BALF Bronchoalveolar lavage fluid CD4 CD8 Cellular immune response Combination domain ELISA enzyme evaluated expected germinal centers IgA IgG IgG anti-spike antibody IgG1 IgG2a immunization immunogenicity immunosorbent in vitro inactivated induce intradermal route lung Lung inflammation mice Neutralization assay Neutralizing titer neutralizing titers neutrophil recruitment New Poly (I:C) poly(I:C positive prefusion produced producing Protein RBD reduced reduction in required SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 virus serum spike Spike protein Subtypes supported T cell Th1 Th1 phenotype the SARS-CoV-2 trimeric vaccination Vaccination strategy Vaccine vaccine. [DOI] 10.3389/fimmu.2022.884760 PMC 바로가기 [Article Type] Article
Effects of Spike Mutations in SARS-CoV-2 Variants of Concern on Human or Animal ACE2-Mediated Virus Entry and Neutralization인간 또는 동물 ACE2 매개 바이러스 진입 및 중화에 대한 우려의 SARS-CoV-2 변이체에서 스파이크 돌연변이의 영향Article Published on 2022-06-292022-09-11 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] ACE2 ACE2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Affect angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 animal animals antibodies antibody Antibody neutralization antibody neutralization activity Beta caused cell entry cell line cell lines circulating common strain comparable concern coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic Delta determine Effect Effectiveness Efficiency Express expressing global health Health host range Human human ACE2 Impact infect infecting information mink MOST Mutation neutralization neutralizing antibody Neutralizing titer neutralizing titers nine omicron Omicron variant over pandemic parental Protein pseudovirus pseudoviruses public policy reduced respiratory reveal S protein S proteins SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 mutation SARS-CoV-2 S protein SARS-CoV-2 spike SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 virus sera several variant several variants severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown significantly socioeconomics spike spike mutations Spread Substitution substitutions Support susceptible tested the S protein the SARS-CoV-2 the SARS-CoV-2 virus therapeutic therapeutic antibodies Transmissibility Transmission Vaccine variant variants variants of concern variety Viral viral cell viral entry viral neutralization virulence virus virus entry virus replication Virus replication. VoC VOCs zoonotic [DOI] 10.1128/spectrum.01789-21 PMC 바로가기 [Article Type] Article
Evaluating the Neutralizing Ability of a CpG-Adjuvanted S-2P Subunit Vaccine Against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variants of Concern중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2) 우려 변종에 대한 CpG-보강 S-2P 소단위 백신의 중화 능력 평가Article Published on 2022-06-102022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] COVID19(2023년), MERS, SARS, 변종, 비임상, 진단, [키워드] Ability acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Against Alpha Alpha variant aluminum aluminum hydroxide antibody Antigen Beta Beta variant beta variants breath clinical trial coated with concern coronavirus coronavirus 2 COVID-19 CpG D614G demonstrated dose effective Effectiveness elicit elicited Evaluating High dose Human humans hydroxide immune response immunization immunized immunogenicity medium neutralization neutralization ability neutralization activity Neutralizing antibodies neutralizing antibody neutralizing capacity Neutralizing titer neutralizing titers Phase 1 prefusion pseudovirus pseudoviruses RAT RATs reduced reduction reduction in respiratory retained S-2P SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variant SARS-CoV-2 variants serum antibodies serum antibody serum sample serum samples severe acute respiratory syndrome Coronavirus significantly Spike protein subject subunit subunit SARS-CoV-2 vaccine the SARS-CoV-2 Vaccine Vaccines variant Variant of concern. variants VOCs wild-type [DOI] 10.1093/cid/ciab711 PMC 바로가기 [Article Type] Article
Omicron-specific mRNA vaccination alone and as a heterologous booster against SARS-CoV-2오미크론 특이적 mRNA 백신 단독 및 SARS-CoV-2에 대한 이종 부스터Article Published on 2022-06-062022-09-11 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 임상, 진단, [키워드] animals Antibody Response assessment background level Beta binding antibody boost booster comparable delta variant elicit generate globe Heterologous homologous immune evasion in vivo increase injection LNP mice mRNA vaccination mRNA vaccine neutralization potency Neutralizing titer neutralizing titers omicron Omicron variant reduce reduction in responses against SARS-CoV SARS-CoV-2 These data titers vaccination Vaccine variant variant of SARS-CoV-2 [DOI] 10.1038/s41467-022-30878-4 PMC 바로가기 [Article Type] Article
Defining the determinants of protection against SARS-CoV-2 infection and viral control in a dose-down Ad26.CoV2.S vaccine study in nonhuman primates비인간 영장류를 대상으로 한 용량 감소 Ad26.CoV2.S 백신 연구에서 SARS-CoV-2 감염 및 바이러스 통제에 대한 보호 결정 요인 정의Article Published on 2022-05-052022-09-11 Journal: PLoS Biology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome antibody Antibody titers Antiviral approach binding antibody coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 determinant disease severity dose-dependent manner Dosing evade Evolution functional Immunity impacted Infection neutralization Neutralizing Neutralizing antibodies neutralizing antibody neutralizing titers NHPs phase receptor Receptor binding respiratory robust SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe coronavirus disease T cell T cells T-cell T-cell immunity Transmission Vaccine Vaccines variant variants Viral viral control while [DOI] 10.1371/journal.pbio.3001609 PMC 바로가기 [Article Type] Article
Fitness of B-Cell Responses to SARS-CoV-2 WT and Variants Up to One Year After Mild COVID-19 – A Comprehensive Analysis경증 COVID-19 이후 최대 1년까지 SARS-CoV-2 WT 및 변이체에 대한 B 세포 반응의 적합성 - 종합 분석Article Published on 2022-05-022022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법, [키워드] Affinity maturation All participants Alpha Anti-RBD antibodies antibodies antibody Antibody Response Antibody responses Antibody titer Antibody titers Antigen antigen-specific memory B cells assays avidity B-cell binding binding antibodies binding antibody Comprehensive correlated COVID-19 declined Delta delta variant domain ELISA ELISPOT evaluate fitness Gamma IgA IgG memory B memory B cell memory B cells memory B-cell Mild N protein neutralization Neutralizing Neutralizing antibodies Neutralizing antibody titer neutralizing antibody titers Neutralizing titer neutralizing titers nucleocapsid participant plasmablast plasmablast responses plasmablasts plasmablasts. post infection predicted Protein remained response SARS-CoV-2 SARS-CoV-2 specific memory B cells SARS-CoV-2 WT significantly increased symptomatic thiocyanate titers variant variants variants of concern waned were assessed were measured wild-type Year [DOI] 10.3389/fimmu.2022.841009 PMC 바로가기 [Article Type] Article
Cross-Variant Neutralizing Serum Activity after SARS-CoV-2 Breakthrough InfectionsSARS-CoV-2 돌발 감염 후 교차 변이 중화 혈청 활성Article Published on 2022-05-012022-09-11 Journal: Emerging Infectious Diseases [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] 2019 novel coronavirus disease activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 B cell Breakthrough infection comparable coronavirus coronavirus disease correlated COVID-19 determine Immunity interval mRNA Neutralizing Neutralizing activity neutralizing antibody neutralizing titers Novel coronavirus novel coronavirus disease respiratory respiratory infections SARS-CoV-2 serum severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 tested vaccination Vaccines variants of concern viruses zoonoses zoonoses. [DOI] 10.3201/eid2805.220271 PMC 바로가기 [Article Type] Article